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KMID : 0383820120730050288
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Tuberculosis and Respiratory Diseases
2012 Volume.73 No. 5 p.288 ~ p.291
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A Case of Typhlitis Developed after Chemotherapy with Irinotecan and Cisplatin in a Patient with Small Cell Lung Carcinoma
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Ji Eun-Hye
Kim Young-Min
Kim Soo-Jeong
Yeom Soo-Jeong
Ha Sung-Eun
Kang Hyeon-Hui
Kang Ji-Young
Lee Sang-Haak
Moon Hwa-Sik
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Abstract
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Typhlitis is a necrotizing colitis that usually occurs in neutropenic patients and develops most often in patients with hematologic malignancies such as leukemia and lymphoma. Typhlitis may proceed to bowel perforation, peritonitis and sepsis, which requires immediate treatment. Irinotecan is a semisynthetic analogue of the natural alkaloid camptothecin which prevents DNA from unwinding by inhibition of topoisomerase I. It is mainly used in colon cancer and small cell lung carcinoma (SCLC), of which the most common adverse effects are gastrointestinal toxicities. To the best of our knowledge, no case of typhlitis after chemotherapy with a standard dose of irinotecan in a solid tumor has been reported in the literature. We, herein, report the first case of typhlitis developed after chemotherapy combining irinotecan and cisplatin in a patient with SCLC.
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KEYWORD
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Typhlitis, Irinotecan, Small Cell Lung Carcinoma
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